Quality Control
Functionality tested in Real-time PCR for specificity, sensitivity and reproducibility for each primer sets using different cell lines, Breast cancer samples and Colon cancer tissues. 

        Targeted Therapy Assay Service           
         NanoCinna Pharmacogenomics Center        

    Targeted therapy

The limitations of chemotherapy, radiotherapy, and surgery are apparent and have been the impetus for developing targeted therapies. Targeted therapy is a type of medication that blocks the growth of cancer cells by interfering with specific targeted molecules needed for carcinogenesis and tumor growth, rather than by simply interfering with rapidly dividing cells (e.g. with traditional chemotherapy). Targeted drugs are active as single agents for the treatment of cancer and offer the opportunity to reverse resistance to chemotherapy and hormonal therapy. Targeted therapies have been established for the treatment of advanced cancers and are now demonstrating benefit in the adjuvant arena. The main categories of targeted therapy are small molecules and monoclonal antibodies. Listed below are a number of targets for these drugs:









      Application
      Evaluation of Radiotherapy sensitivity




    Sampling Condition
 
         Fresh or snap-frozen tumor and its tumor
         borderline are needed, for more information
         please contact us


     Catalog Number
        #S1377    Targeted therapy assay
        #S1378    Her2, EpCAM and EGFR assay
        #S1379    C-kit and PDGFR assay 
        #S1380    SRC assay
        #S1381    FLT3 assay
        #S1382    EML4-ALK assay
        #S1383    VEGF and VEGFR assay
  




      #S1377 description

NanoCinna evaluates the Targeted therapy for solid tumor with expression analysis of 10 genes: 
       
1- Her2/neu                                                                         
2- EGFR                                                   
3- VEGF                                                     
4- FLT3                                             
5- PDGFR                                                 
6- SRC                                                       
7- EML4-ALK                                            
8- C-kit                                      
9- VEGFR2                            
10- EpCAM                                                                                              
 


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NanoCinna Technologists Ltd - Tehran, IRAN
NanoCinna NanoBiotechnology Center
NanoCinna Pharmacogenomics Center

NanoCinna Bioinformatics Center
Target (Gene) Name
Drug Name
HER2/neu
Trastuzumab
EpCAM
Catumaxomab, Edrecolomab
ErbB (HER1 or EGFR)
Cetuximab, Panitumumab, Erlotinib, Gefitinib, Vandetanib
VEGF-A
Bevacizumab
CD20
Ibritumomab, Ofatumumab, Rituximab, Tositumomab
CD52
Alemtuzumab
CD33
Gemtuzumab
EGFR and HER2/neu
Afatinib, Lapatinib, Neratinib
C-kit and PDGFR
Axitinib, Pazopanib, Sunitinib, Sorafenib, Toceranib
FLT3
Lestaurtinib
VEGFR
Axitinib, Cediranib, Pazopanib, Regorafenib, Semaxanib, Sorafenib, Sunitinib, Toceranib, Vandetanib
bcr-abl
Dasatinib, Imatinib, Nilotinib
Src
Bosutinib
Janus kinase 2
Lestaurtinib
EML4-ALK
Crizotinib


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