Quality Control
Functionality tested in Real-time PCR for specificity, sensitivity and reproducibility for each primer sets using different cell lines, Breast cancer samples and Colon cancer tissues.
Chemotherapy Resistance Assay Service
NanoCinna Pharmacogenomics Center
Chemotherapy Resistance
The development of drug-resistant cancers is considered to be the most significant obstacle to the cure of cancer today. Nearly half of all patients with cancer suffer from tumors that are intrinsically resistant to chemotherapy, and most of the remaining half develop drug resistance during the course of their treatment.
Chemotherapy resistance occurs when the cancer cells are resisting the effects of the chemotherapy. You may hear statements like the "cancer chemotherapy failed." If a cancer becomes resistant to one drug or group of drugs, it is more likely that the cancer may be resistant to other drugs. This is why it is very important to select the best possible treatment protocol first. In other words, when treating cancer, one should use the best weapon when there is the smallest possibility of chemotherapy resistance.
There are several possible reasons for chemotherapy resistance:
- Large number of malignant cells
- Proliferation status and cell cycle phase
- Ability to repair damage and/or respond to stress
- Deficient cell death mechanisms
- Use of agents that modify the response, e.g., radical
- scavengers
- Use of antagonistic combinations of drugs
- Intrinsic and acquired resistance to cytotoxic drugs
- Physiological mechanisms
- Alteration in drug metabolism
- Increased drug extrusion
Application
Evaluation of Chemotherapy sensitivity
Sampling Condition
Fresh or snap-frozen tumor and its tumor
borderline are needed, for more information
please contact us
Catalog Number
#S1375 Chemotherapy resistantce assay
#S1375 description
NanoCinna evaluates the chemotherapy resistante with expression analysis of 30 genes:
ATM NFkB SOD1 CASP3
BRCA1 VEGF GPX1 CASP9
BAX p21 CCND1 CASP7
BCL2 p27 ERCC1 BIRC5
EGR1 BCLxL CHK2 TP53
TOP2A AIF TOP1 CytoC
ABCC1 ABCB1 ABCA2 ABCG2
GSTP1 MMP9
